The Human Organ Preservation Effort, or HOPE, is a government initiative tasked with curbing the problem of black market sales of kidneys by regulating the process. This film juxtaposes scenes from the H.O.P.E transplant orientation seminar with the lives of three donors at different stages of the donation process. Following the donors through post surgery, the operation and the donation screening, H.O.P.E. explores the viability of a regulated kidney donation program.